OUDE Hypoforum

Inleveren van 50 mcg Thyrax/Euthyrox, en je krijgt er 20 mcg T3 voor terug, eenmaal daags.
Ofwel kreeg je bij inlevering van de 50 mcg ThyraxEuthyrox, er weer 50 mcg Thyrax/Euthyrox bij. Dat wisten de onderzoekers en de deelnemers niet.

Uiteindelijk bleek dat van de deelnemers maar liefst 49% een voorkeur had voor T4/T3, terwijl 15% een voorkeur had voor T4/T4.

Dat is nog nooit zo uitgesproken geweest.
Eindelijk goed nieuws!

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Effect of combination therapy with thyroxine (T4) and 3,5,3'-triiodothyronine versus T4 monotherapy in patients with hypothyroidism, a double-blind, randomised cross-over study

Study design: Double-blind, randomised cross-over. Fifty micrograms of the usual T4 dose was replaced with either 20 µg T3 or 50 µg T4 for 12 weeks, followed by cross-over for another 12 weeks. The T4 dose was regulated if needed, intending unaltered serum TSH levels.

Evaluation: Tests for quality of life (QOL) and depression (SF-36, Beck Depression Inventory, and SCL-90-R) at baseline and after both treatment periods.

Inclusion criteria: Serum TSH between 0.1 and 5.0 mU/l on unaltered T4 substitution for 6 months.

Results: A total of 59 patients (55 women); median age 46 years. When comparing scores of QOL and depression on T4 monotherapy versus T4/T3 combination therapy, significant differences were seen in 7 out of 11 scores, indicating a positive effect related to the combination therapy. Forty-nine percent preferred the combination and 15% monotherapy (P=0.002). Serum TSH remained unaltered between the groups as intended.

Conclusion: In a study design, where morning TSH levels were unaltered between groups combination therapy, (treated with T3 20 µg once daily) was superior to monotherapy by evaluating several QOL, depression and anxiety rating scales as well as patients own preference.

http://www.eje-online.org/cgi/content/abstract/161/6/895