OUDE Hypoforum

Journal of Autoimmune Diseases

Immunogenetics of Hashimoto's thyroiditis

Abstract
Hashimoto's thyroiditis (HT) is an organ-specific T-cell mediated disease.
It is a complex disease, with a strong genetic component. To date, significant progress has been made towards the identification and functional characterization of HT susceptibility genes.
In this review, we will summarize the recent advances in our understanding of the genetic input to the pathogenesis of HT.

Epidemiology and clinical features of Hashimoto's thyroiditis

Figure 1. Possible pathogenic mechanism of Hashimoto's thyroiditis.

Pathogenesis of Hashimoto's thyroiditis
Autoimmunity in Hashimoto's thyroiditis

Figure 2. A scheme of autoimmune events in Hashimoto's thyroiditis.

Apoptosis in Hashimoto's thyroiditis

Genetics of Hashimoto's thyroiditis
Evidence for genetic susceptibility to Hashimoto's thyroiditis

Animal models of autoimmune thyroiditis

Human Leukocyte Antigen class I and II genes

HLA class III genes and non-HLA genes of the HLA region

CTLA-4 gene

Other immune regulatory genes

Thyroid-specific genes

Apoptotosis-related genes

Other genes

Non-defined susceptibility loci for Hashimoto's thyroiditis and autoimmune thyroid disease
Conclusion